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The Best audio books websiteAll the audio books information you need to know about is right
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Netscape Corporation has created the best known secure server technologies. It uses a security protocol called Secure Sockets Layer (SSL) that provides data encryption, server authentication, message integrity and optional client authentication for a TCP/IP connection. When a client seeking to purchase audio books connects with a secure server, they exchange a *handshake* which initiates a secure session. With this protocol, the same server system can run both secure and unsecured web servers simultaneously. This means an audio books organization or company can provide some information to all users using no security, and other information that is secured. For example, a business that sells audio books online can have its storefront (merchandise catalog) unsecured, but ordering and payment forms can be secure. Why are these developments important? As the Internet becomes a way to buy and sell audio books products and services, financial transactions become essential. Right now, most audio books transactions involve the exchange of credit card information, either directly over the network, or by phone, to complete a transaction initiated online. Eventually, you will be able to use cash as well as credit, directly over the network. There are two basic kinds of digital cash, anonymous cash and identified cash. Anonymous cash is just like paying for audio books with paper cash but it also carries no information about the person making the transaction, and leaves no transaction trail. You create it by using numbered bank accounts and blind signatures. Identified cash, on the other hand, contains information revealing the identity of the person who withdrew it from the bank. Like credit card transactions, identified cash can be tracked as it moves through the system and involves fully identified accounts and non-blind signatures. Whether you use digital cash when purchasing audio books is entirely up to you. We suggest you employ the purchasing avenues available from the audio books supplier we recommend. audio books
You can spend a few hours looking on the Net for information about audio books or you can take advantage of the research we have done for you. There are literally hundreds of thousands of web pages with some kind on information on audio books but much is of little value. Jeeves is a good source for information about audio books but you must filter through the commercials for audio books and determine if that is really what you want. This means you must make a decision on the value from this particular audio books store. You are welcome to spend your valuable time in this research or you can rely on the fact that we have done it for you and click the links on the left side of this page. New Findings on the Role of Glutathione in Cancer by: Priya F Shah
Cancer cells and normal cells are known to respond differently to nutrients and drugs that affect glutathione status. Numerous studies have shown that tumor cells have elevated levels of glutathione levels, which confers resistance to chemotherapy drugs. One of the challenges of cancer therapy is how to deplete tumor cells of glutathione, so as to make them more vulnerable to the effects of chemotherapy drugs, while at the same time allowing normal cells to remain relatively unaffected by chemotherapeutic drugs. A number of new findings have emerged that take into consideration the role of glutathione in pathways that promote programmed cell death (apoptosis) in cancer cells. A German study has reported that glutathione (GSH) plays a critical role in cellular mechanisms that result in cell death. The study found that cancer cells resistant to apoptosis had higher intracellular GSH levels. Depletion of glutathione in these tumor cells made them more vulnerable to the effects of anticancer drugs or the gene that promotes apoptosis (CD95 or APO-1/Fas). The researchers concluded that apoptosis resistance in tumor cells depends, at least in part, on intracellular GSH levels. (1) In another study conducted in Spain, researchers found that lowering GSH concentration may be convenient not only for the efficiency of chemotherapy, but also to induce a rather fast and direct apoptosis mechanism in tumor cells. (2) Based on that premise that the glutathione-S-transferase enzyme is expressed at high levels in many tumors, researchers at the Fox Chase Cancer Center in Pennsylvania, went on to design a novel prodrug (PABA/NO). The glutathione-s-transferase in tumor cells converts PABA/NO to lethal nitric oxide, resulting in death of the tumor cell. The prodrug was shown to have antitumor effects in an animal model for human ovarian cancer. (3) In the fourth study, Polish researchers found that ingesting a selenium supplement is beneficial, as a supportive element in chemotherapy. (4) Selenium is a co-factor of the enzyme glutathione peroxidase [GSH-P(x)] and was found to significantly increase the activity of GSH-P(x) in patients reciving the supplement. A previous clinical study by the same researchers recommended the administration of selenium in patients with ovarian cancer undergoing multi-drug chemotherapy. (5) Another interesting study by researchers in Texas showed that your chances of surviving a type of brain cancer, called primary malignant glioma, could depend on the type of glutathione-s-transferase (GST) gene you were born with. Having a combination of a two specific variants of GST (germ-line GSTP1*A/*A and GSTM1 null genotype) confers a survival advantage in some types of brain cancers, but also comes with an increased risk of adverse events related to chemotherapy. (6) There is compelling evidence to suggest a crucial role for glutathione and substances that target glutathione metabolism in the prevention and treatment of cancer. Undenatured whey protein is one of the natural foods known to selectively deplete cancer cells of their glutathione, thus making them more susceptible to such cancer treatments as radiation and chemotherapy. For a complete report on the research on undenatured whey protein and cancer see the report Glutathione (GSH) and Whey Protein in Cancer. http://www.1whey2health.com/cancer_glutathione.htm Disclaimer: The information here is not provided by medical professionals and is not intended as a substitute for medical advice. Please consult your physician before beginning any course of treatment. References: 1. Friesen C et al. [Cell Death and Differentiation advance online publication, 23 April 2004] 2. Tormos C et al. [Cancer Lett. 2004 May 10;208(1):103-13.] 3. Findlay VJ et al. [Mol Pharmacol. 2004 May;65(5):1070-9.] 4. Sieja K et al. [Gynecol Oncol. 2004 May;93(2):320-327.] 5. Sieja K. [Pharmazie. 1998 Jul;53(7):473-6.] 6. Okcu MF et. al. [Clin Cancer Res. 2004 Apr 15;10(8):2618-25.] Copyright © 2004 Priya Shah
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