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Many silent breeze 462 websites invite you to sign a Guestbook. They are not just doing this to get warm fuzzy feelings. silent breeze 462 retailers who are seriously committed to quality customer service want feedback. The best sort of silent breeze 462 feedback comes from silent breeze 462 shoppers. Makes sense doesn't it? When you take the time to sign a silent breeze 462 Guestbook you are adding value to the relationship you have with the silent breeze 462 retailer. You may be able to offer valuable suggestions which will improve the silent breeze 462 shopping experience for other customers. silent breeze 462
Your search for silent breeze 462 is over. After spending many weeks totally researching the subject and buying products, we've set this website up to show you our results and keep you informed of the latest developments in silent breeze 462. Sometimes it's not exactly easy to find just what you're looking for. So we're glad you found us, and I'm sure that you'll find this site and those we link to very useful and informative. After purchasing silent breeze 462 online always check your credit card statements. Identify purchase which you know you have made, like your silent breeze 462 purchase, and always challenge with your bank any piurchases that you cannot identify. Doing these things will ensure your online purchases are safe and rewarding. New Findings on the Role of Glutathione in Cancer by: Priya F Shah
Cancer cells and normal cells are known to respond differently to nutrients and drugs that affect glutathione status. Numerous studies have shown that tumor cells have elevated levels of glutathione levels, which confers resistance to chemotherapy drugs. One of the challenges of cancer therapy is how to deplete tumor cells of glutathione, so as to make them more vulnerable to the effects of chemotherapy drugs, while at the same time allowing normal cells to remain relatively unaffected by chemotherapeutic drugs. A number of new findings have emerged that take into consideration the role of glutathione in pathways that promote programmed cell death (apoptosis) in cancer cells. A German study has reported that glutathione (GSH) plays a critical role in cellular mechanisms that result in cell death. The study found that cancer cells resistant to apoptosis had higher intracellular GSH levels. Depletion of glutathione in these tumor cells made them more vulnerable to the effects of anticancer drugs or the gene that promotes apoptosis (CD95 or APO-1/Fas). The researchers concluded that apoptosis resistance in tumor cells depends, at least in part, on intracellular GSH levels. (1) In another study conducted in Spain, researchers found that lowering GSH concentration may be convenient not only for the efficiency of chemotherapy, but also to induce a rather fast and direct apoptosis mechanism in tumor cells. (2) Based on that premise that the glutathione-S-transferase enzyme is expressed at high levels in many tumors, researchers at the Fox Chase Cancer Center in Pennsylvania, went on to design a novel prodrug (PABA/NO). The glutathione-s-transferase in tumor cells converts PABA/NO to lethal nitric oxide, resulting in death of the tumor cell. The prodrug was shown to have antitumor effects in an animal model for human ovarian cancer. (3) In the fourth study, Polish researchers found that ingesting a selenium supplement is beneficial, as a supportive element in chemotherapy. (4) Selenium is a co-factor of the enzyme glutathione peroxidase [GSH-P(x)] and was found to significantly increase the activity of GSH-P(x) in patients reciving the supplement. A previous clinical study by the same researchers recommended the administration of selenium in patients with ovarian cancer undergoing multi-drug chemotherapy. (5) Another interesting study by researchers in Texas showed that your chances of surviving a type of brain cancer, called primary malignant glioma, could depend on the type of glutathione-s-transferase (GST) gene you were born with. Having a combination of a two specific variants of GST (germ-line GSTP1*A/*A and GSTM1 null genotype) confers a survival advantage in some types of brain cancers, but also comes with an increased risk of adverse events related to chemotherapy. (6) There is compelling evidence to suggest a crucial role for glutathione and substances that target glutathione metabolism in the prevention and treatment of cancer. Undenatured whey protein is one of the natural foods known to selectively deplete cancer cells of their glutathione, thus making them more susceptible to such cancer treatments as radiation and chemotherapy. For a complete report on the research on undenatured whey protein and cancer see the report Glutathione (GSH) and Whey Protein in Cancer. http://www.1whey2health.com/cancer_glutathione.htm Disclaimer: The information here is not provided by medical professionals and is not intended as a substitute for medical advice. Please consult your physician before beginning any course of treatment. References: 1. Friesen C et al. [Cell Death and Differentiation advance online publication, 23 April 2004] 2. Tormos C et al. [Cancer Lett. 2004 May 10;208(1):103-13.] 3. Findlay VJ et al. [Mol Pharmacol. 2004 May;65(5):1070-9.] 4. Sieja K et al. [Gynecol Oncol. 2004 May;93(2):320-327.] 5. Sieja K. [Pharmazie. 1998 Jul;53(7):473-6.] 6. Okcu MF et. al. [Clin Cancer Res. 2004 Apr 15;10(8):2618-25.] Copyright © 2004 Priya Shah
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